Carcinogen List The following is a list of substances NIOSH considers to be potential occupational carcinogens. Aniline is a chemical byproduct of treated coal tar, which was an abundant waste product of the time. EPA calculated an inhalation unit risk estimate of 4.9 × 10 -3 (µg/m 3)-1. Aniline has been classified as very toxic in humans, with a probable oral lethal dose in humans at 50 to 500 milligrams per kilogram body weight (mg/kg). It is therefore not possible to determine a level of intake for aniline which may be regarded as safe for humans. Dietary Supplement Label Database (DSLD): The Dietary Supplement Label Database (DSLD) (https://dsld.od.nih.gov) includes full label derived information from dietary supplement products marketed in the U.S. with a Web-based user interface that provides ready access to label information. The American Cancer Society looks to these organizations to evaluate the risks based on evidence from laboratory, animal, and human research studies. Uses advised against Food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300 CHEMTRECÒ, … Loading… VOL. The process for converting aniline, which has the odor of rotten fish, to a colored dye when treated by acids was discovered by accident in England in 1856. • USEPA: suggests that Aniline could be a suspected carcinogen and there is no evidence of being carcinogenic by itself. Serious poisoning may result from ingestion of 0.25 mL. Until recently, these inadequate experiments plus the publication of a series of epidemiologic studies that exonerated aniline as a bladder carcinogen have led to the belief that aniline is not a carcinogen. Aniline can cause methemoglobin formation, and liver and endocrine effects. But interestingly, we have seen that aniline has started to appear on restricted substance lists, which … It is soluble in water, ether, ethanol and most organic solvents. In addition to the concerns related to the genotoxicity and carcinogenicity, it can cause methemoglobinemia and haemolytic anaemia after long term exposure. Based on animal studies the Panel concluded that aniline should be considered as a carcinogen [ 3 ]. : 4 (1974) (p. 27) 5. In the past, benzidine was used to produce dyes or products used in clinical laboratories. The approximate minimum lethal dose for a 150 lb. aniline in adult man is about 0.21 mg/kg body weight Chronic exposure Anemia, headaches, tremor, parathesia, pain, narcosis or coma, and cardiac arrhythmia. There is no legal or scientific reference or study related safe limit values for aniline. However, benzidine has not been sold in the United States since the mid-1970s. This category is only used when sufficient indications of carcinogenicity for humans are available. carcinogen. Inhaling Aniline can irritate the nose and throat. o-Toluidine is toxic and a potential human carcinogen. It is considered to have high acute toxicity, based on short-term animal tests in rats. Nitrobenzene is toxic and poisonous. Acetanilide can be produced by reacting acetic anhydride with aniline: C 6 H 5 NH 2 + (CH 3 CO) 2 O → C 6 H 5 NHCOCH 3 + CH 3 COOH. (4) EPA uses mathematical models, based on human and animal studies, to estimate the probability of a person developing cancer from breathing air containing a specified concentration of a chemical. Aniline has been evaluated as a carcinogen. Benzidine is a manufactured chemical. N-Nitroso-N-methylaniline (NMA) is an esophageal carcinogen in the rat. human is 10 grams. www.efsa.europa.eu. Is Aniline Carcinogen? Aniline is classified as a suspected carcinogen (carcinogen category 2) under the Classification, Labelling and Packaging Regulation (CLP) in the EU. List of Classifications. The exposure circumstance entails exposures that are carcinogenic to humans. Some authorities class aniline as a carcinogen, although the IARC lists it in Group 3 (not classifiable as to its carcinogenicity to humans) due to the limited and contradictory data available. Current OSHA PEL: 5 ppm (19 mg/m3) TWA [skin] 1989 OSHA PEL: 2 ppm (8 mg/m3) TWA [skin] 1993-1994 ACGIH TLV: 2 ppm (7.6 mg/m3) TWA [skin] Description of substance: Colorless to brown, oily liquid with an … NIOSH REL: None established; NIOSH considers aniline to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990]. Classification of carcinogenicity: Overall summary evaluation of carcinogenic risk to humans is Group 3: The agent is not classifiable as to its carcinogenicity to humans. Based on animal and human evidence, several expert agencies have evaluated the cancer-causing potential of benzene. Aniline may therefore cause cancer at even the slightest level of exposure. A number of the carcinogen classifications deal with groups of substances: aniline and homologs, chromates, dintrotoluenes, arsenic and inorganic arsenic compounds, beryllium and beryllium compounds, cadmium compounds, nickel compounds, and crystalline forms of silica. References ^ Thomas Kahl, Kai-Wilfrid Schröder, "Aniline" in Ullmann's Encyclopedia of Industrial Chemistry 2007; John Wiley & Sons: New York. Beginning of August 2012, 108 agents are classified in Group 1 of IARC. the industry in general does not consider aniline as a risk from a consumer safety perspective. Aniline can cause skin irritation and rash. This site is now being updated and maintained for access by the NIH Office of Dietary Supplements : A740I-4; A740I-500 CAS-No 62-53-3 Synonyms Phenylamine; Aminobenzene; Benzenamine (Certified ACS) Recommended Use Laboratory chemicals. Aniline CAS RN: 62-53-3 Carcinogenicity Evidence. The International Agency for Research on Cancer (IAR Exposure levels at the garment stage, especially those having undergone garment-washing processes, were low. GROUP 1: the agent may be a carcinogenic mixture for humans (proven carcinogen or certainly carcinogenic). It causes kidney, urethra, bladder, and hematological neoplasia. The formation of methemoglobin interferes with the oxygen-carrying capacity of the blood. 1) Aniline is a skin and eye irritant and a mild dermal sensitizer. What are aniline dyes and how did such a plant end up in Nyack? Given new scientific evidence, it cannot be excluded that aniline ’s carcinogenic potential is due to damage to the genetic material of the cells. The human carcinogen potency factor (q1*) for aniline is .026 (mg/kg/day)-1 for oral exposure. ... Metolachlor can increase the incidence of liver tumors in rats and has been classified as a possible human carcinogen (Monsanto, 1991; Wilson and Takei, 1999; Heydens et al., 2010). The Reportable Quantity (RQ) value of 1, 10, 100, 1000, or 5000 pounds is used to determine the quantity of a hazardous substance for which notification is required in the event of a release as specified by CERCLA based on chronic toxicity. The present paper shows that AZB clearly induces micronuclei in the bone marrow of rats at a dose of 375 mg/kg and above. Heart, kidney, and liver damage may also occur, possibly as secondary effects of hemolysis Considered a Non Threshold carcinogen : A Heinz-body hemolytic crisis may follow the development of methemoglobinemia by 2 to 7 days. EPA has classified hydrazine as a Group B2, probable human carcinogen. In mice, however, only a marginally positive … Aniline does, however, induce intrachromosomal recombination between repeated sequences in Saccharomyces cerevisiae, resulting in deletion (DEL) of intervening sequences. Aniline should be handled as a CARCINOGEN--WITH EXTREME CAUTION. Azobenzene (AZB) is non-carcinogenic in mice, but a potent rat carcinogen, inducing tumours in the spleen and other abdominal organs. 000062-53-3 Aniline 3 27, Sup 7 1987 000090-04-0 ortho-Anisidine 2B Sup 7, 73 1999 000104-94-9 para-Anisidine 3 27, Sup 7 1987 000191-26-4 Anthanthrene 3 92, Sup 7 2010 000120-12-7 Anthracene 3 92, Sup 7 2010 000118-92-3 Anthranilic acid 3 16, Sup 7 1987 000084-65-1 Anthraquinone 2B 101 2013 001309-64-4 Antimony trioxide 2B 47 1989 001345-04-6 Antimony trisulfide 3 47 1989 000052-46-0 … ANILINE. The same carcinogen can give rise to tumors of different kinds and locations, depending on the site of application, and a given type of tumor can be caused by different substances. Aniline is an organic compound with the formula C 6 H 5 NH 2 which has the IUPAC name Phenylamine. Product Name Aniline Cat No. BUT, rats that ate food contaminated with aniline for life developed cancer of the spleen. The carcinogen aniline is negative in the Ames Salmonella mutagenicity assay. Aniline is a colourless, oily liquid which turns brown on exposure to light and air. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. 5.2 Human carcinogenicity data At the present time, the weight of epidemiological evidence suggests that aniline is not a carcinogen for the human bladder. Chronic Effects . (A substance that causes cancer or helps cancer grow is called a carcinogen.) Its EINECS register number is 200-539-3 and CAS register number is 62-53-3. CLASSIFICATION: B2; probable human carcinogen. LEL: … It is toxic and a suspected carcinogen which is readily absorbed by the skin. The available studies in humans are inadequate to determine whether exposure to aniline can increase the risk of developing cancer in people. The International Agency for Research on Cancer (IARC) determined that aniline is not classifiable as to its carcinogenicity to humans. 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